ABSTRACT
Objective: To compare the outcomes in term of hospital stay and mortality between vaccinated and nonvaccinated covid-19 patients. Study Design: Prospective/Observational Place and Duration: The study was conducted at Medicine department of Fauji Foundation Hospital Rawalpindi and Pak International Medical College Hayatabad Peshawar for six months duration from December 2020 to May 2021. Methodology: One hundred ten patients of either gender with covid-19 disease were enrolled. All the patients were confirmed with RT PCR. Patients were randomly divided in to two groups. Group I (vaccinated) comprised of 45 patients and group II (non-vaccinated) comprised of 65 patients. Severity of disease, hospital stay and mortality were compared between both groups. Data was analyzed by SPSS 24.0. Results: There were 74 (67.27%) males while 36 (32.73%) patients were females. Mean age of patients was 50.54±12.76 years. Mean BMI was 26.23±2.44 kg/m2. 10 (22.22%) patients in vaccinated group and 40 (61.54%) in nonvaccinated group had severe covid-19 disease, a significant difference was observed regarding severity of disease between both groups with p-value <0.05. Mortality rate and hospital stay were also high in nonvaccinated patients as compared to vaccinated (p-value <0.05). Conclusion: It is concluded that non-vaccinated patients of covid-19 had prolonged hospital stay and high rate of severity of disease and mortality as compared to vaccinated patients.
ABSTRACT
Objective: The aim of this study is to determine the comparison of adverse outcomes in cirrhotic and non-cirrhotic patients presented with coronavirus disease. Study Design: Place and Duration: The department of Medicine of Divisional Headquarters Teaching Hospital Mirpur Azad Kashmir and Mohiuddin Teaching Hospital, Mirpur AJK for six months during the period from October 2020 to March 2021. Methodology: Total 80covid-19 patients of both genders with or without chronic liver disease were enrolled in this study. Patients were aged between 20-55 years. Patients were divided in to two groups. Group I (with cirrhosis 40 patients) and group II (without cirrhosis 40 patients). Outcomes in term of mortality between both groups were examined. All the data was analyzed by SPSS 26.0 version. Results: There were 24 (60%) males and 16 (40%) were females with mean age 44.19 +/- 7.65 years in group I while in group II 27 (67.5%) and 13 (32.5%) patients were males and females with mean age 43.62 +/- 5.34 years. We found that mortality rate among patients of group I (cirrhotic) had high mortality rate13 (32.5%) as compared to patients without cirrhosis 5 (12.5%) in group II with p-value 0.0003. Conclusion: We concluded in this that frequency of adverse outcomes was significantly high among cirrhotic patients with coronavirus disease as compared to non-cirrhotic patients.
ABSTRACT
Objective:To determine the effectiveness of prone positioning in patients of covid-19 deisease presented with respiratory failure. Study Design: Retrospective/Observational study Place and Duration: Medicine department of BKMC/MMC, Mardan and Mohiuddin Teaching Hospital, Mirpur AJK for six months during the period from August 2020 to January 2021. Methods: Total 100 patients of respiratory failure admitted to ICU were included in this study. Patients detailed demographics age,sex and body mass index were recorded after taking informed written consent. Patients were aged between 25-80years.Patients were divided in to two groups I and II. Group A had 50 COVID-19 patients underwent prone position and group Bwith50 patients taken as control. Chest X-ray of both groups were taken. Patients of group A were kept in prone position whilegroup B received invasive ventilation and follow up was taken in duration of 15-days. Reduction of intubation rate, mortality, hospital stay and complications were identified among both groups. Complete data was analyzed by SPSS 22.0 version. Results:Majority of the patients was males 76% and the rest were females 24%. Mean age of the patients in prone positioning group was 52.42 +/- 13.18 years with mean BMI 26.14 +/- 7.13 kg/m(2) and in control group A itwas 50.44 +/- 14.65 years with mean BMI 26.41 +/- 7.13 kg/m(2). 55% patients had moderate and 45% had severe covid-19 disease. Mean duration of prone position was 5.14 +/- 6.31 hours. Most of the patients 81% had bilateral lung involvementinterstitial infiltrates. Fever, cough and dyspnea were the most common symptom found in both groups. Mean PF ratio was increases in prone group as compared to controlled group. Mean hospital stay in group A was 12.9 +/- 4.76 days and in group B mean hospital stay was 17.32 +/- 10.24 days. Mortality in group A was 3 (3%) and in group Bmortality was found in 7 (7%). No any severe complications were observed among both groups. Conclusion:We concludedin this study that the use of prone position among patients of COVID-19 was effective and safe method to reduce intubation, mortality and hospital stay. There was no any complication were found after this treatment.